If you are using Clone Manager Professional version 9, you can download a software patch that will update your program to the latest version (ver 9.02). This update makes a number of small corrections, adds a new function for joining sequences, and updates the find sequence module to support mismatches. You can also download an updated version of the program's compiled HTML Help.
A number of alignment algorithms have been optimized to increase the speed of alignment, particularly for large near-perfect alignments, and you can now save the results of a Compare Two Sequences operation and later re-open this file. Corrections have been made to the display of base numbers following a protein alignment displayed as DNA, primer 5' extensions are now shown when these extensions span the top of the molecule, simple sequence assemblies can now handle very small overlaps, and the dialog tree for adding a primer to a collection now allows scrolling.
This update also includes a new function to help you to join two sequences to create a larger molecule. You can select to append, splice, or insert one sequence to another. Molecule features (genes, regions, etc) will be retained and enzyme sites can be auto-scanned or rebuilt from existing site lists. The Find Sequence module has been updated so you can now find places in the sequence that nearly match a specific pattern of bases. You can allow limited mismatches or mismatches and gaps or insertions when comparing the molecule sequence to the specified search sequence.
This update includes the changes made in incremental update 9.01, including the new function to help you design a set of primers for sequencing.
Click below to begin the download to your computer. When prompted, select Save to write a copy of the file to your hard disk.
Download software patch update (1081 KB) now
For Individual User and Small WorkGroup Licenses, the license holder can install the update. First, make sure Clone Manager Professional is not in use. Then double-click on the downloaded file CMPUp902.exe to start the update process. The incremental update program will search your computer system, looking for an eligible program copy to update. If it finds a copy of Clone Manager Professional 9.0x, it will be updated to Clone Manager Professional 9.02.
For Concurrent User Licenses, the Network Administrator should install the update. The update must be performed at the computer that is the license server and under the account used to install the software. (The computer that is the license server will have the file C:\Program Files\SciEdLicense\SciEdLicense.exe.) First, make sure Clone Manager Professional is not in use. Then double-click on the downloaded file CMPUp902.exe to start the update process. The incremental update program will check your computer system, looking for an eligible program copy to update. If it finds a copy of Clone Manager Professional 9.0x, it will be updated to Clone Manager Professional 9.02.
You can download the compiled HTML Help file for Clone Manager Professional 9 to replace an earlier version of this file. Users running the network version of the program can use this file to provide local help access, eliminating the need to try to load a compiled help file across network security barriers.
Click below to begin the download to your computer. When prompted, select Save to write a copy of the file to your hard disk.
Download compiled HTML help file (358 KB) now
After download, move the downloaded file CMSuite9.chm to your Clone Manager home directory. (The default home directory is C:\CMHome. To check your home directory location: in Clone Manager, click File, Preferences and then look on the Basic tab in the Location field. Users running the network version should have assigned a home directory on their local machine.) When a new help file is placed in your home directory, Clone Manager will use this file in preference to the help file originally installed.
You may need to unblock this help file before use. In File Explorer, right-click on the help file CMSuite9.chm and select Properties from the menu. Click the Unblock button (lower right) on the General page and then click Apply. If you do not see the Unblock button, you may need to log on as administrator.
Help topics for the new Join Sequences function and the updated Find Sequence module implemented in update 9.02 are provided in a two-page PDF document. You can open this file to view or print using Adobe Acrobat.
View/print supplemental help document SHlp_902.pdf now
Help topics for the Sequencing Primer Wizard added in update 9.01 are provided in a three-page PDF document. You can open this file to view or print using Adobe Acrobat.
For use with Clone Manager Professional 9.
If you are using Clone Manager Basic, please select the Clone Manager Basic update (on menu at left).
If you are unsure which edition of Clone Manager you are using, you can start Clone Manager and then click Help, About Clone Manager.
The About box will provide you with the program name/edition, license type, and your program serial number.