If you are using Clone Manager Professional version 9, you can download a software patch that will update your program to the latest version (ver 9.2). This update adds a new module to retrieve Entrez files, a new module that supports Topoisomerase cloning, and a number of modifications to provide additional support for GenBank file features. You can also download the latest version of the program's compiled HTML Help.
This update includes a new Retrieve from Entrez (E-utils) function. You can now retrieve sequence files from the Entrez system at NCBI using a new module that can directly access the NCBI file system (instead of using the Entrez web site browser interface). Once you locate the file you need, you can view the file in GenBank format or import the molecule for immediate use in Clone Manager.
This update also includes a new Topoisomerase Cloning Wizard to simulate cloning using Topo® Cloning techniques (Invitrogen Corp). It will help you select the appropriate components, show you the proposed result, and create the resulting recombinant molecule.
With this update, you can now read in segmented features (joins) when importing GenBank files and you can enter join segments for your own sequence files, as needed. Clone Manager also can now read in, display, and retain feature qualifiers for imported GenBank files. You can specify the codon start of a feature and set the translation table (genetic code) to be used for translation for your molecule. The Clone Manager XML format (*.cx5) has also been updated to use UTF-8 encoding to support international characters.
This update also includes all corrections and additions made in prior version 9 incremental updates, including a new join sequences function, an updated find sequence search with limited mismatches, a new sequencing primer wizard, and a new Gateway Cloning Wizard that helps you to simulate cloning using Gateway® Recombination Cloning techniques (Invitrogen Corp).
Concurrent User License holders -- this update also includes a network administrator's toolkit. These administrator tools will help you to install and configure the software, turn on token logging, monitor tokens in use, and trouble-shoot problems you may encounter running the network edition of Clone Manager.
Individual or WorkGroup (Seat) License holders can download and install the incremental software update. Click below to begin the download to your computer. When prompted, select Save to write a copy of the file to your hard disk.
After download, make sure Clone Manager Professional is not in use. Then double-click on the downloaded file CMPUp920.exe to start the update process. The incremental update program will search your computer system, looking for an eligible program copy to update. If it finds a copy of Clone Manager Professional 9.x, it will be updated to Clone Manager Professional 9.2.
For Concurrent User Licenses, the Network Administrator should download and install the update. Click below to begin the download.
The update must be performed at the computer that is the license server and under the account used to install the software. (The computer that is the license server will have the file C:\ProgramFiles\SciEdLicense\SciEdLicense.exe.)
First, make sure Clone Manager Professional is not in use. Then double-click on the downloaded file nCMPU920.exe to start the update process. The incremental update program will check your computer system, looking for an eligible program copy to update. If it finds a copy of Clone Manager Professional 9.x, it will be updated to Clone Manager Professional 9.2 and the network administrator tools will be installed.
Network Admin Tools documentation is included with the patch update download. For immediate review, please see the Network Admin Documents section (left panel menu item).
You can download the compiled HTML Help file for Clone Manager Professional 9 to replace an earlier version of this file. Users running the network version of the program can use this file to provide local help access, eliminating the need to try to load a compiled help file across network security barriers.
Click below to begin the download to your computer. When prompted, select Save to write a copy of the file to your hard disk.
After download, move the downloaded file CMSuite9.chm to your Clone Manager home directory. (The default home directory is C:\CMHome. To check your home directory location: in Clone Manager, click File, Preferences and then look on the Basic tab in the Location field. Users running the network version should have assigned a home directory on their local machine.) When a new help file is placed in your home directory, Clone Manager will use this file in preference to the help file originally installed.
You may need to unblock this help file before use. In File Explorer, right-click on the help file CMSuite9.chm and select Properties from the menu. Click the Unblock button (lower right) on the General page and then click Apply. If you do not see the Unblock button, you may need to log on as administrator.
Help topics for the new Retrieve from Entrez (E-utils) module and the new Topoisomerase Cloning Wizard added in update 9.2 are provided in a four-page PDF document. You can open this file to view or print using Adobe Acrobat.
Help topics for the new Gateway Cloning Wizard added in update 9.1 are provided in a four-page PDF document. You can open this file to view or print using Adobe Acrobat.
Help topics for the Join Sequences function and the updated Find Sequence module implemented in update 9.02 are provided in a two-page PDF document. You can open this file to view or print using Adobe Acrobat.
Help topics for the Sequencing Primer Wizard added in update 9.01 are provided in a three-page PDF document. You can open this file to view or print using Adobe Acrobat.
For use with Clone Manager Professional 9.
If you are using Clone Manager Basic, please select the Clone Manager Basic update (on menu at left).
If you are unsure which edition of Clone Manager you are using, you can start Clone Manager and then click Help, About Clone Manager.
The About box will provide you with the program name/edition, license type, and your program serial number.